Detalhe da pesquisa
1.
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Cell
; 184(12): 3143-3162.e32, 2021 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34004147
2.
Exploring germline recombination in Nestin-Cre transgenic mice using floxed androgen receptor.
Genesis
; 58(10-11): e23390, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32744751
3.
Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker.
Mol Pharm
; 15(10): 4568-4576, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30107748
4.
An Evaluation of Optimal PEGylation Strategies for Maximizing the Lymphatic Exposure and Antiviral Activity of Interferon after Subcutaneous Administration.
Biomacromolecules
; 18(9): 2866-2875, 2017 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28731677
5.
Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site.
Nanomedicine
; 13(8): 2485-2494, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28821463
6.
A Comparison of the Pharmacokinetics and Pulmonary Lymphatic Exposure of a Generation 4 PEGylated Dendrimer Following Intravenous and Aerosol Administration to Rats and Sheep.
Pharm Res
; 33(2): 510-25, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26486513
7.
PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration.
Mol Pharm
; 12(3): 794-809, 2015 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25644368
8.
Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.
Mol Pharm
; 12(2): 432-43, 2015 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25485615
9.
Molecular weight (hydrodynamic volume) dictates the systemic pharmacokinetics and tumour disposition of PolyPEG star polymers.
Nanomedicine
; 11(8): 2099-108, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26343493
10.
Assessing Protein Expression in Patient-Derived Xenografts Using Western Blotting.
Methods Mol Biol
; 2806: 209-218, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38676805
11.
Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation.
Mol Pharm
; 9(3): 355-73, 2012 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22250750
12.
Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models.
Mol Pharm
; 9(3): 422-32, 2012 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22233281
13.
A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems.
Nanomedicine
; 8(1): 103-11, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21704192
14.
Mapping Motor Neuron Vulnerability in the Neuraxis of Male SOD1G93A Mice Reveals Widespread Loss of Androgen Receptor Occurring Early in Spinal Motor Neurons.
Front Endocrinol (Lausanne)
; 13: 808479, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35273564
15.
Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers.
Mol Pharm
; 8(2): 338-49, 2011 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21171585
16.
Dissociation of disease onset, progression and sex differences from androgen receptor levels in a mouse model of amyotrophic lateral sclerosis.
Sci Rep
; 11(1): 9255, 2021 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33927243
17.
Dysregulation of Steroid Hormone Receptors in Motor Neurons and Glia Associates with Disease Progression in ALS Mice.
Endocrinology
; 161(9)2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32621747
18.
Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis.
Br J Pharmacol
; 176(13): 2111-2130, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30849180
19.
Doxorubicin Conjugation and Drug Linker Chemistry Alter the Intravenous and Pulmonary Pharmacokinetics of a PEGylated Generation 4 Polylysine Dendrimer in Rats.
J Pharm Sci
; 107(9): 2509-2513, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29852134
20.
Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery.
J Control Release
; 272: 17-28, 2018 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29305921